ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Gender, Smoking, Folate And Vitamin B12 On Plasma Homocysteine Concentration
Sezer ÇALIŞKAN, MD,a Filiz KURALAY, MD,a Banu ÖNVURAL, MDa
aDepartment of Biochemistry, Dokuz Eylul University School of Medicine,, İZMİR
Objective: Total homocysteine (tHcy) metabolism is dependent on several vitamins; (e.g., folate and the vitamins B12, B6 and B2). There have been, however, conflicting results about other factors such as age, gender and smoking that may influence plasma total homocysteine concentrations. The aim of this study is to investigate whether and how gender, smoking and levels of vitamin B12 and folate affect the concentrations of plasma tHcy.
Material and Methods: We measured plasma tHcy concentrations in 48 healthy subjects who were divided into four equal groups according to sex and smoking habits. tHcy and vitamin levels were measured, respectively, by fleurescence polarization immunoassay and electrochemiluminescence.
Results: There was no difference in tHcy concentrations between the groups with regard to either gender and smoking habits. Among men, tHcy significantly correlated with folate (rho= -0.597, p=0.003) and B12 (rho=-0.472, p=0.023). tHcy levels correlated with vitamin B12. In smoker subgroups of both genders, tHcy concentrations correlated with none of the vitamins in question.
Conclusion: It appears that smoking does not directly affect tHcy metabolism. These controversial results may be due to altered vitamin status as a consequence of dietary factors.Keywords: Homocysteine, vitamin B12, folate, smokingTurkiye Klinikleri J Med Sci 2004, 24:35-38
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