ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Risk Assessment Of Organophosphate Pesticide Exposure On Greenhouse Workers In Menderes Region, Develi Village (turkey)
N.Ülkü KARABAY,a Berna ÇAKMAK,a Ferah SAYIM,a M.Günnehir OĞUZa
a Department of Biology, Ege University School of Science, İZMİR
Objective: Plasma cholinesterase (PChE) activities are widely used to determine the rate of exposure to organophosphate (OP) pesticides. The aim of our study was to determine the existence of any symptomatic and biochemical effects of OP pesticide exposure during pesticide application in workers.
Material and Methods: Blood samples were collected from 53 male greenhouse workers exposed to pesticides for 2-30 years in Develi Village. PChE levels were determined spectrophotometrically and chromatographic analysis were carried out on (gas chromatography/nitrogen phosphorus detector) (GC/NPD) for residue analysis.
Results: A decrease in PChE levels was observed (mean ± SD; 878 ± 90.2 nmol/min/mL plasma) when compared to control (mean±SD; 1706 ± 102.4 nmol/min/mL plasma). Symptoms were nausea, eye irritation and ophthalmia, headache, fatigue and anorexia, skin disease, coughing, gasping for breath and asthma, dizziness and coma. No organophosphate pesticide residue was detected in blood specimens of the workers.
Conclusion: Significant inhibition of PChE activity and clinical symptoms were observed in the workers, indicating a potential toxicological hazard from OP pesticide exposure.Keywords: Organophosphate insecticide, worker, plasma cholinesterase activity, residue analysisTurkiye Klinikleri J Med Sci 2004, 24:6-11
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