ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Postmenopausal Hormone Replacement Therapy On Lens Opacities And Intraocular Pressure
Aysel PELİT, MD,a Ebru TARIM, MD,b Aykut PELİT, MD,c Yonca AYDIN AKOVA, MDd
Departments of aOphthalmology, bObstetrics and Gynecology, Başkent University, Faculty of Medicine,
Adana Teaching and Medical Research Center,
cDepartment of Biophysics, Çukurova University, Faculty of Medicine, ADANA
dDepartment of Ophthalmology, Başkent University, Faculty of Medicine, ANKARA
Objective: The aim of this study was to determine whether different postmenopausal hormone replacement therapies (HRT) reduced age-related cataract and influenced intraocular pressure (IOP).
Material and Methods: One hundred forty eight women on HRT for at least 4 years were included in this prospective study. Group 1 (n= 34) was on 2 mg of 17 beta estradiol, group 2 (n= 41) was on 2 mg of 17-beta estradiol and 1 mg of norethisterone acetate, and group 3 (n= 35) took 2.5 mg of tibolone. The control group (n= 38) did not take HRT. We investigated the association between postmenopausal HRT, lens opacities and IOP in different groups. Lens status was evaluated through a dilated pupil by means of a standardized grading system. The IOP was measured by a single examiner with standard Goldmann applanation tonometry. The tonometric value was considered the mean of three consecutive measurements.
Results: The mean ages in the control group, group 1, group 2, and group 3, were 52.44 ± 5.89, 50.87 ± 3.53, 52.05 ± 4.60, and 51.05 ± 3.07, respectively. There were no significant differences between the groups regarding age (p= 0.143) and among the 3 groups regarding HRT years (p= 0.176). We did not observe any significant difference between the groups with respect to the frequency of nuclear opacity (p= 0.361), cortical opacity (p= 0.960), and posterior subcapsular opacity (p= 0.856). In addition, there were no significant differences when we compared the IOP findings between the groups (p= 0.847).
Conclusion: These findings suggest that HRT for 4 years is not protective against lens opacity, and does not modify IOP.Keywords: Cataract; hormone replacement therapy; menopause; intraocular pressureTurkiye Klinikleri J Med Sci 2007, 27:811-815
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