ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Evaluation Of Kaposi Sarcoma Patients Diagnosed At A Single Center
Dr. Gülsüm Emel PAMUK,a
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b Dr. Salim DÖNMEZ,a Dr. Yusuf YE-ŞİL,b Dr. Emre TEKGÜNDÜZ, a
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b Dr. Burhan TURGUT, a
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b Dr. Muzaffer DEMİRa
,
b
aİç Hastalıkları ABD, bHematoloji BD, Trakya Üniversitesi Tıp Fakültesi, EDİRNE
Objective: To determine the general clinical features, treatment modalities and response to treatment in 5 Kaposi sarcoma (KS) patients diagnosed at our center.
Material and Methods: Five patients diagnosed with KS at Trakya University Medical Faculty, Department of Internal Medicine, Division of Hematology between October 2001-October 2006 were retrospectively evaluated.
Results: KS developed secondary to immunosuppression in four of five patients, one had classical type KS. Four patients were males, and one was female. The diagnoses in patients who used immunosuppressive therapy were aplastic anemia, Hodgkin lymphoma, MDS-RAEB II, and chronic inflammatory demyelinating polyneuropathy (CIDP). We discontinued immunosuppressive therapy and administered vincristine in the aplastic anemia patient. KS lesions disappeared spontaneously although chemotherapy continued in the Hodgkin lymphoma case. KS lesions were present on initial presentation in the patient with MDS-RAEB II; there was prominent progression after chemotherapy and regression was achieved after paclitaxel. KS lesions disappeared spontaneously in the CIDP patient after discontinuation of corticosteroids. In the patient with classical type KS, KS lesions regressed after adriamycin and one persistent big lesion was surgically excised.
Conclusion: There was partial or complete improvement of KS lesions after discontinuation of immunosuppressive drugs in some of our patients and with systemic chemotherapeutics in the others. As the diagnosis of this disease requires suspicion in especially early stages, hematologists should consider KS in the differential diagnosis of skin lesions in their immunosuppressive patients and a skin biopsy should be obtained.Keywords: Sarcoma, kaposi; immunosuppressionTurkiye Klinikleri J Med Sci 2007, 27:658-663
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