ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Investigation Of The Relationship Between Rheumatoid Factor Positivity And Parvovirus B19 Seropositivity
Dr. H. Handan AKBULUT,a Dr. Mehmet ÖZDEN,a Dr. İlhami ÇELİK,b Dr. S. Serdar KOCA,c Dr. Vedat BULUTa
aİmmünoloji ABD, bKlinik Mikrobiyoloji ve Enfeksiyon Hastalıkları ABD, cİç Hastalıkları ABD, Fırat Üniversitesi Tıp Fakültesi, ELAZIĞ
Objective: It is suggested that the Human Parvovirus B19 (HPV B19) can be responsible for the etiology or triggering the autoimmune diseases that affecting joints and connective tissues in adults and children. In this study, the possible relationship between HPV B19 IgM and IgG antibodies and rheumatoid factor (RF) positivity was investigated in patients with (RF) positivity who admitted to Department of Rheumatology with complaints of common arthralgia and locomotor system.
Material and Methods: RF positive 50 patients and 20 healthy volunteers were included in the study. The levels of anti-HPV B19 IgM and IgG antibodies (with ELISA), ANA with IFA on Hep-2 cells and CRP with nephelometry were studied in serum samples obtained from the patients and controls.
Results: Although the rate of anti-HPV B19 IgM positivity was higher in patients than controls this was not statistically significant (p> 0.05). No significant difference was observed between Anti-HPV B19 IgG positivity of the patients and controls (p> 0.05). 46% ANA positivity was detected in RF positive patients, no ANA positivity was observed in RF negative controls (p< 0.05). No statistically significant difference was observed in terms of HPV B19 IgM and IgG antibody positivity in patients who had rheumatoid arthritis or not. HPV B19 IgM positivity was highly significant in patients with ANA positivity than those without ANA positivity.
Conclusions: No significant relationship was observed with the parvovirus infections of the patients who had complaint of arthralgia and problems of locomotors system with RF positivity. However, significance of HPV B19 IgM positivity in patients with ANA positivity was interpreted that it was verified the probable relationship between the autoimmune diseases and parvovirus infections.Keywords: Parvovirus B19, human; rheumatoid factor; antibodies, antinuclearTurkiye Klinikleri J Med Sci 2007, 27:654-657
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