ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Prevalance Of Autoantibodies In Chronic Hbv And Hcv Patients
Dr. İlhan AFŞAR,a Dr. Aslı Gamze ŞENER,a Dr. Nükhet KURULTAY,a Dr. Metin TÜRKERa
aMikrobiyoloji ve Klinik Mikrobiyoloji Laboratuvarı, Atatürk Eğitim ve Araştırma Hastanesi, İZMİR
Objective: To investigate the presence of anti nuclear antibody (ANA), anti mitochondrial antibody (AMA), anti smooth muscle antibody (ASMA) and liver kidney microsomal antibody (ALKM) in patients with chronic HBV and HCV infections.
Material and Methods: One hundred and two chronic HBV patients positive for HBs Ag and HBV DNA and 98 chronic HCV patients positive for anti-HCV antibody and HCV RNA were included in the study. Ninety serum samples negative for HBs Ag and anti-HCV comprised the control group. Chemiluminescence technique, VITROS (Ortho-Clinical Diagnostics) was used to determine HBs Ag and anti-HCV. The levels of HBV DNA and HCV RNA were determined quantitatively by real time polymerase chain reaction. Indirect immunofluorescence antibody technique was used for autoantibody (ANA, AMA, ASMA, ALKM) detection in the patient and control groups. Data were analyzed using the statistical package for social science software, version 10.0 and the prevalence in patient and control groups were compared using the chi-square test.
Results: Of the 102 patients with chronic HBV infection and of the 98 patients with chronic HCV infection, 30 (29.4%) and 28 (28.5%) were positive for autoantibodies, respectively. ANA was the most common antibody in both patient groups (66.6% ANA, 12.6% ASMA in HBV patients and 65.3% ANA, 3% AMA, 7% ASMA, 1% ALKM in HCV patients). Autoantibodies were positive in 13 (14.4%) of the 90 control serum samples. The results of the other autoantibodies were not statistically significant.
Conclusion: This study indicates that autoantibodies are more prevalent among patients with chronic HBV and HCV infections and they should be investigated in chronic liver infections.Keywords: Hepatitis B; hepatitis C; autoantibodyTurkiye Klinikleri J Med Sci 2007, 27:649-653
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