ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Familial Adenomatous Polyposis: Report Of Three Male Siblings
Dr. Hayrullah DERİCİ,a Dr. Tuğrul TANSUĞ,a Dr. Enver REYHAN,a Dr. Cemal KARA,a Dr. Okay NAZLI,a Dr. Ali Doğan BOZDAĞa
a3. Genel Cerrahi Kliniği, Atatürk Eğitim ve Araştırma Hastanesi, İZMİR
Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome, where polyps develop throughout the gastrointestinal tract, particularly the colon and the rectum. It is due to a genetic mutation that interferes with the normal function of adenomatous poliposis coli, an important gene that controls the rate of cells growth. Although colon polyps may become cancerous during the teenage years, this happens more commonly in the second and third decades. By age 40, almost all untreated patients will have developed colon cancer.
We aimed to present our surgical approach towards 3 male siblings, 2 of which had developed colorectal cancer, and one had intramucosal cancer with the diagnosis of FAP.Keywords: Adenomatous polyposis coli; colorectal neoplasms; proctocolectomy, restorativeTurkiye Klinikleri J Med Sci 2007, 27:629-632
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