ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Candida Biofilm And Infections Related To Medical Devices: Medical Education
Dr. Sema KEÇELİ ÖZCANa
aMikrobiyoloji ve Klinik Mikrobiyoloji ABD, Kocaeli Üniversitesi Tıp Fakültesi, KOCAELİ
In the recent years, the use of implanted or non-implanted medical devices (catheters, joint prostheses, valvular prostheses etc..) have been increasing. Such devices cause bacterial infections as well as fungal infections with a high mortality and morbidity. Fungal infections of medical devices occur mostly due to pathogenic Candida species, especially Candida. albicans, Candida tropicalis and Candida parapsilosis. A virulence factor of Candida, biofilm production on the surface of medical devices, plays a major role in the pathogenesis of infection. The structure of Candida biofilm is mostly dependent on environmental conditions (surface composition, glucose content etc.), Candida morphogenesis and Candida species. Non-albicans Candida species produce less biofilm than Candida albicans. The antifungal resistance of Candida biofilm is a major factor for the pathogenesis of infection. The possible mechanisms of antifungal resistance are the amount of extracellular matrix, slow growth rate and shortage of nutrition, overexpression of membrane localized efflux pumps (MDR1, CDR1 ve CDR2 genes) and the amount of sterol in biofilm. Medical devices in which Candida biofilm and infections are detected are central venous catheters, urinary catheters, joint prostheses, arteriovenous fistulas and grafts, peritoneal dialysis catheters, valvular prostheses, pacemakers, cardioverter defibrillators, ventricule assistant devices and ventriculoperitoneal shunts. This paper reviews the structure of Candida biofilm, the mechanism of infection, the antifungal resistance of biofilm and the mechanisms of resistance and medical devices causing Candida infections.Keywords: Biofilms; equipment and supplies; CandidaTurkiye Klinikleri J Med Sci 2007, 27:589-600
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