ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Growing Importance And Newly Defined Roles Of Mast Cells In Microbiology: Medical Education
Dr. Azize Yasemin GÖKSU,a Dr. Öner ÖZDEMİRb
aMikrobiyoloji ve Klinik Mikrobiyoloji ABD, Süleyman Demirel Üniversitesi Tıp Fakültesi, ISPARTAbÇocuk Sağlığı ve Hastalıkları ABD, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, ABD
Mast cells (MCs) are multifunctional cells that are well recognized with their functions in allergic diseases and certain types of parasitic infections. However, their essential contribution to other aspects of host defence and immune regulation has only recently begun to be widely accepted. Until recently, MCs have been considered primarily harmful because of their role in potentially fatal anaphylactic reactions. Nevertheless, there is also growing evidence for their contribution to human health. Animal models of bacterial infections repeatedly demonstrated that MCs played a critical role in host defence, and in some models, the presence of MCs was crucial for host survival. Data on their involvement in early responses of innate immunity to other pathogens is also increasing. The sentinel role of MCs in host defence should be considered in the light of recent data mentioned in this article while prescribing the drugs, which were demonstrated to have inhibitory effects on mast cell functions e.g. degranulation or mediator release, such as glucocorticoids, cyclosporine and cromolynes. This review summarizes newly defined functional aspects of human MCs, and emphasizes their unique role in host defence.Keywords: Mast cells; microbiologyTurkiye Klinikleri J Med Sci 2007, 27:577-588
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