ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Molecular Pathogenesis Of Pancreatic Cancer: Review
Dr. Fikret ŞAHİN,a Mehmet TAŞPINAR,b Dr. Asuman SUNGUROĞLUb
aMikrobiyoloji ve Klinik Mikrobiyoloji ABD, bTıbbi Biyoloji ABD, Ankara Üniversitesi Tıp Fakültesi, ANKARA
Pancreatic cancer is among the most fatal cancer types due to the difficulty in diagnosis and treatment. Better understanding of the molecular pathogenesis of pancreatic cancer will facilitate early diagnosis and treatment. Recently, numerous genetic and epigenetic alterations ranging from point mutations to chromosomal changes have been described. Such changes involved in the pathogenesis of the disease include K-Ras2 mutation, Her2/Neu gene overexpression, CDKN2A/p16 gene deletion, mutation and hypermethylation, inactivation of BRCA2, MADH4/SMAD4/DPC genes and changes in expression of STK11 and p53 genes. In this review, we aimed to outline the molecular pathogenesis of pancreatic cancer and describe new diagnosis and treatment approaches with in the light of new findings.Keywords: Pancreatic neoplasms, molecular biology, etiologyTurkiye Klinikleri J Med Sci 2007, 27:560-566
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