ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Regulation Of Immune Response With Signaling Lymphocyte Activation Molecule Related Receptors: Review
Dr. Nesrin DEMİR,a Dr. Fulya İLHANa
aİmmünoloji ABD, Fırat Üniversitesi Tıp Fakültesi, ELAZIĞ
The (SLAM)-related receptors (SRR) group includes CD150 (SLAM), CD244 (2B4), CD84, CD299 (Ly-9), NTB-A (Ly-108), and CD319 (CRACC: CD2-like receptor-activating cytotoxic cells). Several adaptive proteins including SLAM associated protein (SAP) have a major role in the signal transduction of the SRR group. These receptors are expressed on many immune system cells. SAP deletion causes many defects in the cellular signaling. X-linked lymphoproliferative syndrome (XLP), which is a severe immune disorder, is the result of SAP deficiency. SRR receptors also may play a significant role in autoimmune diseases such as systemic lupus erythematosis (SLE), rheumatoid arthritis (RA) and in tuberculosis. Here, we review the current understanding of SRR function in different immune cells.Keywords: Lymphoproliferative disorders; SH2D1A protein, human; signal transductionTurkiye Klinikleri J Med Sci 2007, 27:540-546
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