ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Correlation Of Elevated Plasma Homocysteine Levels With Insulin Resistance Regardless Of Obesity In Polycystic Ovary Syndrome
Dr. Şebnem AKTARAN,a Dr. Ersin AKARSU,a Dr. Ahmet ÇELİK,b Dr. Orçun ALTUNÖRENa
aEndokrinoloji ve Metabolizma Hastalıkları BD, bBiyokimya BD, Gaziantep Üniversitesi Tıp Fakültesi, GAZİANTEP
Objective: The polycystic ovary syndrome (PCOS) shares some components of metabolic syndrome. Thus, women with PCOS are at high risk for the possible development of early-onset cardiovascular disease (CVD). Increased levels of plasma homocysteine (pHcy) were shown to be a significant risk factor for CVD and are associated with insulin resistance (IR). Therefore, we investigated the correlation of pHcy with IR and obesity in patients with PCOS.
Material and Methods: A total of 36 women with PCOS were divided into two groups according to body mass index (BMI) as group 1 (nonobese: BMI <25 kg/m2) and group 2 (overweight and obese: BMI ≥25 kg/m2). Two groups were compared with each other and the control group for basal hormones, pHcy, lipids, fasting blood insulin (FI) and glucose (FG), vitamine B12, folic asit, BMI, waist to hip ratio (WHR) and homeostasis model assessment (HOMA-R). Correlations of pHcy with IR and BMI were analyzed.
Results: Basal hormone levels (LH/FSH, estradiol, testosterone, DHEA-S, cortisol), pHcy, FI, HOMA-R, triglyceride, Ferriman Gallwey Score (FGS) and diastolic blood pressure in PCOS were significantly higher than those in controls. FG level was not different. HDL was low. Obese patients with PCOS had higher HOMA-R, FI, testosterone, estradiol, triglyceride and FGS than nonobese patients. PHcy was significantly correlated with IR and FI but not with BMI, WHR, age, FG and FGS.
Conclusion: IR, atherogenic dyslipidemia, obesity and elevated pHcy in PCOS indicate a high risk for CVD. Correlations of pHcy with IR may be noticeable for a prediction of premature atherosclerosis.Keywords: Polycystic ovary syndrome; homocysteine; obesity; hyperinsulinismTurkiye Klinikleri J Med Sci 2007, 27:508-512
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