ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Homocysteine Levels And Lipid Profile In Hemodialysis Patients
Dr. Haluk DÜLGER,a Dr. Tuğba GÜR,a Dr. Hayriye SAYARLIOĞLU,b Dr. M. Ramazan ŞEKEROĞLU,a Dr. Reha ERKOÇ,c Dr. Hüseyin BEĞENİKc
aBiyokimya ABD, cİç Hastalıkları ABD, Yüzüncü Yıl Üniversitesi Tıp Fakültesi, VANbİç Hastalıkları ABD, Kahraman Maraş Sütçü İmam Üniversitesi Tıp Fakültesi, KAHRAMANMARAŞ
Objective: The aim of this study was to investigate the levels of homocysteine and lipid profiles in patients included in hemodialysis programs for chronic renal failure (CRF).
Material and Methods: The patients were divided into 2 groups and each group consisted of 30 patients, leading to a total of 60 patients. On the other hand, 20 healthy people comprised the control group. The first group (nontreated CRF) included new patients without a previous history of dialysis or any medical treatment; the second group (treated CRF) included patients who have received medical treatment [vitamin B12 (1 mg/month) and folic acid (15 mg/week)] and dialysis for at least the last 5 years. Serum total homocysteine, vitamin B12, folic acid, creatinine, triglyceride, total cholesterol, HDL, LDL, VLDL, cholesterol levels were measured in all patients and the control group.
Results: Levels of homocysteine were high in group 1 and group 2 patients (respectively p< 0.01, p< 0.05), whereas serum HDL cholesterol levels in group 2 were low compared to those in the control group (p< 0.01). In addition, a negative correlation was observed between homocysteine and folic acid levels in group 2 patients (r= -0.48, p< 0.01).
Conclusion: The results of this study showed that homocysteine levels in CRF increased and this increase was lower in group 2 patients. Administration of folic acid reduced the levels of homocycstein. Thus, we suggest that folic acid may be a significant factor to prevent the progression of chronic renal failure.Keywords: Kidney failure, chronic; homocystein; lipidsTurkiye Klinikleri J Med Sci 2007, 27:491-495
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