ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Grading Of The Ovarian Serous Cystadencarcinomas, And Its Correlation With Brca1 And P53 Immunoreactivity
Dr. Nedim GÜNEŞ,a Dr. Fahri YILMAZ,b Dr. Ali Kemal UZUNLARc
aPatoloji Bölümü, Siirt Devlet Hastanesi, SİİRTbPatoloji AD, Abant İzzet Baysal Üniversitesi İzzet Baysal Tıp Fakültesi, BOLUcPatoloji AD, Dicle Üniversitesi Tıp Fakültesi, DİYARBAKIR
Objective: Ovarian cancer is a gynecological malignancy with the higest mortality. The surface epithelial tumors of the ovary are the most common cancer types. The purpose of this study was to grade the ovarian serous cystadenocarcinomas and to evaluate BRCA1 and p53 proteins immunohistochemically.
Material and Methods: Fifty-eight cases diagnosed as serous cystadenocarcinomas of the ovary were selected for this study. The cases were graded according to two-tier grading system, FIGO and Shimizu-Silverberg grading system and the results were compared. The BRCA1 and p53 proteins were studied immunohistochemically.
Results: The cases were distributed as follows: according to the two-tier grading system low grade 12 (21%) cases and high grade 46 (79%) cases; according to the FIGO grading system grade I 9 (16%) cases, grade II 29 (50%) cases, and grade III 20 (34%) cases and according to the Shimizu-Silverberg grading system grade I 11 (19%) cases, grade II 29 (50%) cases, and grade III 18 (31%) cases. Positive p53 staining was detected in 57% (33/58) and BRCA1 was detected in 67% (39/58) of the cases. The relationship between p53 and BRCA1 proteins and histopathologic grade was analyzed. High grade ovarian serous carcinomas had a higher rate of p53 expression (65%) compared to low grade (25%) tumors. BRCA1 immunstaining was detected in 92% (11/12) of low grade and 61% (28/46) of high grade tumors according to two-tier grading system.
Conclusion: There is a good correlation between the two-tier grading system and the FIGO and the Shimizu-Silverberg grading systems. In addition, the application of the two-tier grading system for ovarian serous carcinomas is easy because this system is based on easily understood two criteria and includes two categories (low grade, high grade). In contrast to p53, high grade tumors had a lower rate of BRCA1 expression (61%) compared to low grade (92%) tumors. In high-grade carcinomas, no statistical correlation was present between the p53 and BRCA1 positivity (p= 0.666).Keywords: Ovary; cystadenocarcinoma; genes, p53; BRCA1 proteinTurkiye Klinikleri J Med Sci 2007, 27:335-343
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