ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Tgf-β (transforming Growth Factor-β) And Signal Transduction: Medical Education
Mustafa SOYÖZ,a Dr. Nurten ÖZÇELİKa
aTıbbi Biyoloji AD, Süleyman Demirel Üniversitesi Tıp Fakültesi, ISPARTA
The transforming growth factor-β (TGF-β) family comprising a large group of extracellular growth factors controls the development of the organism. TGF-β family members consists of a large number of structurally related polypeptide growth factors, each capable of regulating a fascinating array of cellular processes including cell proliferation, differentiation, motility, adhesion, and death. TGF-β and related factors play a prominent role in the development, homeostasis and repair of virtually all tissues in organisms.
TGF-β and related factors regulate gene expression by bringing together two types of receptor serine/treonine protein kinases. One of these kinases phosphorylates the other, which in turn phosphorylates SMAD proteins. SMADs are a novel family of signal transducers that move into the nucleus and generate transcriptional complexes of specific DNA-binding ability. Upon ligand activation of the receptor complex, the type I receptor kinase phosphorylates specific SMADs, which then forms a complex with Smad4 and moves into the nucleus. In the nucleus, these complexes, either alone or in association with a DNA-binding subunit, activate target genes by binding to specific promoter elements.
Alterations of TGF-β signaling pathways underlie many human disorders. A loss of growth inhibitory responses to TGF-β is often observed in cancer cells. A gain of TGF-β activity is thought to play a central role in fibrotic disorders characterized by excessive accumulation of interstitial matrix material in the lung, kidney, liver, and other organs.Keywords: Transforming growth factor beta; smad proteins; signal transductionTurkiye Klinikleri J Med Sci 2007, 27:426-433
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