ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Human Mast Cell Cytotoxicity Against Human Tumor Cells And Mechanisms: Medical Education
Dr. Öner ÖZDEMİRa
aAllerji, İmmünoloji BD, Pediatri AD, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, College of Medicine, Cincinnati, OH, ABD
Human mast cells (MC) can act as effectors of the human innate immune system in addition to their known roles in allergic disorders. Reported data on human MC’s possible role as anti-tumor cells are very controversial even though first observations were reported in 1950s. Moreover, there is no reported data on in vivo human MC cytotoxicity (MCC) against human tumor cells. In vivo observations from human pathological specimens are also very debatable. Mounting evidence also indicates that MCs could either promote or inhibit tumor growth probably depending on environmental conditions. Currently, those that believe in the inhibitory role of MCs assume them as inhibitors of tumor development through their cytotoxic pro-necrolytic/-apoptotic granules. In fact, MC has been also long believed to have either TNF-a-dependent or independent natural cytotoxicity against murine TNF-a sensitive tumor cells in the long term incubations. TNF-a independent pathways such as chymase were also assumed to contribute to MCC. Nonetheless, some still consider MCs as enhancers of tumor development through their angiogenic effects. Their theories were based on pathological specimen observations showing an association between increased MC counts and the poor prognosis in some cancers such as cervical cancer. Here, the implications of our earlier study showing human MCC against human myeloid leukemia and lymphoma cells are also discussed. Although TNF- and chymase seem to be the most important components of MCC; the other mechanisms are also mentioned. Comprehensive study and understanding of human MC interactions with tumor cells hopefully give us new treatment options in cancer treatment.Keywords: Mast cell neoplasms; angiogenesis; cytotoxicity; immunologicTurkiye Klinikleri J Med Sci 2007, 27:99-106
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