ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Levels Of Carboxy-terminal Propeptide Of Type 1 Procollagen Do Not Reflect The Severity Of Nonalcoholic Steatohepatitis
Abdullah OKAN, MD,a Ethem TANKURT, MD,a Defne SABUNCUOĞLU, MD,b Abdullah SONSUZ, MD,c Gül GÜNER, MD,b Özgül SAĞOL, MD,d Gülşen ÖZBAY, MD,e Ömür GÖNEN, MDa
Departments of aGastroenterology, bBiochemistry, dPathology, Dokuz Eylül University Medical School, İZMİRDepartments of cHepatology, ePathology, İstanbul University Cerrahpaşa Medical School, İSTANBUL
Objective: High serum levels of carboxy-terminal propeptide of Type 1 procollagen (PICP) were reported in patients with chronic viral hepatitis, alcoholic liver disease and cirrhosis as a marker of liver fibrosis. However, its status in nonalcoholic steatohepatitis (NASH) is uncertain. The aim of this study was to determine serum PICP levels in NASH patients comparing with cirrhotic patients and healthy individuals, and its association with the degree of necroinflammatory activity and fibrosis.
Material and Methods: PICP levels were measured by a specific enzyme immunoassay in 29 patients with biopsy-proven NASH, 18 patients with cirrhosis and 18 healthy controls. Histological grading and staging for NASH group were evaluated using Brunt’s classification and the scores were compared with their PICP levels.
Results: Compared to controls (mean ± SD: 57.4 ± 17 ng/mL), PICP levels were significantly higher in cirrhotics (120.67 ± 102 ng/mL) and NASH patients (92.78 ± 33.6 ng/mL) [p= 0.004 and p< 0.001, respectively]; however, the concentrations did not differ between NASH and cirrhotic patients (p> 0.05). PICP levels did not correlate with necroinflammatory activity and fibrosis scores in NASH patients.
Conclusion: Serum PICP levels are elevated in NASH patients, similar to those with cirrhosis; however they do not reflect the degree of histological grade and stage.Keywords: Procollagen Type 1 carboxy terminal peptide, liver cirrhosisTurkiye Klinikleri J Med Sci 2007, 27:27-31
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