ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Investigation Of Serum C-reactive Protein And Malondialdehyde Levels In Patients With Colon Cancer
Dr. Mehmet Refik BAYRAKTAR,a Dr. Murat HARPUTLUOĞLU,b Dr. Nihayet Mehmet BAYRAKTARc
aMikrobiyoloji AD, bGastroenteroloji AD, cBiyokimya AD, İnönü Üniversitesi Tıp Fakültesi, MALATYA
Objective: CRP is a non-specific acute phase reactant produced by the liver as a consequence of cytokine stimulation. MDA is a marker of lipid peroxidation associated with oxidative stress. This study aimed to investigate the relation of serum CRP and MDA with colon cancer.
Material and Methods: The study comprised 35 colon cancer patients and 30 healthy controls. Serum CRP was measured using Behring Nephlometer analyzer 100 while MDA was measured in a spectrophotometer based of its reaction with thiobarbitruic acid and the development of red color.
Results: Serum CRP and MDA levels were higher in colon cancer patients than those of controls and they were statistically significant.
Conclusion: As in other diseases, CRP and MDA are elevated in colon cancer and most probably associated with oxidative reactions and tiusse damage involved in the pathology of colon cancer.Keywords: Colonic neoplasms; C-reactive protein (164-173); oxidative stressTurkiye Klinikleri J Med Sci 2007, 27:13-15
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