ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Sulfur-containing Antioxidants On Malondialdehyde And Catalase Levels Of Liver, Kidney And Brain In Lead-exposed Rats
Emrah ÇAYLAK,a İhsan HALİFEOĞLUb
aBiyokimya ve Klinik Biyokimya AD, Fırat Üniversitesi Tıp Fakültesi,bbBiyokimya, Fırat Üniversitesi Tıp Fakültesi Dekanlığı, ELAZIĞ
Objective: Lead causes a great environmental problem because it is widely used in the industry. Several studies focusing on its effects on human and animals were carried out. Sulphur containing antioxidants were observed to have beneficial effects against lead’s detrimental properties in experimental studies. The aim of our study was to evaluate the antioxidant effects of some sulphur-containing compounds in rats where oxidative stress was induced by lead acetate.
Material and Methods: Oxidative stress parameters were determined (Hb in whole blood, MDA and CAT in liver, kidney and brain) in rats following the administration of lead and sulphur containing antioxidants [L-methionine, lipoic acid (LA), N-acetylcysteine (NAC), L-homocysteine (L-Hcy)].
Results: In the lead group Hb levels were determined to be significantly low (p< 0.01) whereas MDA levels were higher compared to controls. Hb levels in lead-methionine and lead-LA groups were significantly lower compared to lead group (p< 0.05). MDA levels of lead-NAC group were reduced in all tissues compared to lead group whereas there was an increase over control values in liver CAT activities (p< 0.05) in lead-LA group. Kidney CAT activities were significantly low in lead-NAC (p< 0.05), and lead-Hcy (p< 0.01) groups compared to lead group.
Conclusion: It is believed that oxidative stress induced by lead is reduced by sulphur-containing compounds.Keywords: Lead; methionine; thioctic acid; acetylcysteine; homocysteineTurkiye Klinikleri J Med Sci 2007, 27:1-8
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