ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Matrix Metalloproteinases And Atherosclerosis: Review
Dr. Buket REELa
aFarmakoloji AD, Ege Üniversitesi Eczacılık Fakültesi, İZMİR
Matrix metalloproteinases (MMPs) are a family of Zn++- and Ca++-dependent neutral endopeptidases that degrade components of extracellular matrix (ECM). The activity of MMPs is essential for many of the processes involved in atherosclerotic plaque formation, such as infiltration of inflammatory cells, smooth muscle cell migration and proliferation. Furthermore, MMPs have also been implicated in events leading to plaque destabilization and rupture. The activity of MMPs is tightly controlled by endogen tissue inhibitors (Tissue inhibitors of metalloproteinases; TIMPs), under physiological conditions. However, during atherosclerotic plaque development, MMP activity is increased by rising cytokine- and growth factor-stimulating gene transcription, elevated zymogen activation and an imbalance in the MMP/TIMP ratio. It is therefore conceivable that inhibition of MMPs or re-establishing the MMP/TIMP balance may be useful in treating the symptoms of atherosclerosis. Recent studies demonstrated that synthethic MMP inhibitors were likely to be useful in treating the symptoms of atherosclerosis. The objective of this review was to assist the better understanding of the effects and contributions of MMPs on the pathogenesis of atherosclerosis. Understanding of the roles of MMPs in the pathogenesis of atherosclerosis may give rise to the proposition of new approaches for the treatment of life-threatening atherosclerotic disorders and to the development of new specific MMP inhibitors as pharmacological agents.Keywords: Matrix metalloproteinase, atherosclerosis, extracellular matrixTurkiye Klinikleri J Med Sci 2006, 26:527-537
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