ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Vitamin D3 And Calcium On Fracture Healing In Rats
Bahadır ASLAN, MD,a Aydıner KALACI, MD,a Murat BOZLAR, MD,c
Esin ATİK, MD,b Ahmet Nedim YANAT,a MD, Arzu TAŞÇI, MDd
Departments of aOrthopaedics and Traumatology, bPathology, Mustafa Kemal University, Faculty of Medicine, HATAY
cOrthopaedic Surgeon, Ermenek Goverment Hospital, KARAMAN
dHealth and Education Center, Middle East Technical University, ANKARA
Objective: We aimed in this study, to evaluate the effects and mechanism of action of single high-dose vitamin D3 and calcium on fracture healing in rats.
Material and Methods: A total of 40 rats were divided into four groups; the first group (Group A) was treated with calcium, the second group (Group B) with vitamin D3, the third group (Group C) with calcium and vitamin D3 combination, and the fourth group was the control group (Group D). Tibiae of the rats were osteotomized by a Gigli saw. All rats were sacrificed 3 weeks after surgery. The results obtained were compared by mechanical testing, histological examination and radiographic evaluation.
Results: Mean radiographic scores were 1.6 ± 0.8 for group D; 1.7 ± 0.8 for group A; 2.3 ± 0.8 for group B; and 2.4 ± 0.7 for group C. There was a statistically significant difference between the mean radiographic scores of only groups C and D (p= 0.037). There was also a statistically significant difference between the corresponding fracture load values of group D and all the other groups (p= 0.000), but there was no such difference between the corresponding fracture load values of the groups A and B (p= 0.208). Mean histological scores were 5.6 ± 2.7 for group D; 6.0 ± 2.7 for group A; 7.0 ± 2.1 for group B; and 7.2 ± 1.9 for group C (p> 0.05).
Conclusion: These results suggested that the real effect of vitamin D on fracture healing was via calcium metabolism. We conclude that calcium and vitamin D given in the early stages of fracture healing gave opportunity for early weight bearing.Keywords: Angiogenesis inducing agents, fracture healing, calcium, cholecalciferolTurkiye Klinikleri J Med Sci 2006, 26:507-513
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