ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Antibiotic Resistance Of Enterococci Isolated From An Intensive Care Unit
Dr. Gülgün YENİŞEHİRLİ,a Dr. Yunus BULUTa
aMikrobiyoloji ve Klinik Mikrobiyoloji AD, Gaziosmanpaşa Üniversitesi Tıp Fakültesi, TOKAT
Objective: Recently, there has been a dramatic increase in the number of nosocomial infections caused by enterococci. Intensive care unit is the part of the hospital with the highest frequency of nosocomial enterococcal infections. Since enterococci are intrinsically resistant to β-lactams and aminoglycosides and they acquired high-level resistance to many other antimicrobial agents, new classes of antimicrobial agents became available in several countries.
Material and Methods: In this study, the in vitro activities of ampicillin, ciprofloxacin, vancomycin, teicoplanin, linezolid and quinupristin/dalfopristin (Q/D) and high level resistance to gentamycin were determined for 137 Enterococcus species (96 E. faecalis and 41 E. faecium) isolated from our intensive care unit.
Results: MICs of vancomycin, teicoplanin, linezolid and Q/D were determined by E-test. All enterococcal isolates were susceptible to vancomycin, teicoplanin and linezolid. High- level resistance to gentamycin was observed in 21.9% of E. faecalis and 26.8% of E. faecium isolates. While ampicillin resistance rate was 16.7% for E. faecalis isolates, it was 73.2% for E. faecium strains. Ninety percent of E. faecalis and 100% E. faecium isolates with high-level resistance to gentamycin were also resistant to ciprofloxacin.
Conclusions: Although Q/D is not available in clinical settings in our country, 7.3% of E. Faecium and 72.9% of E. faecalis isolates were resistant to this drug.Keywords: Enterococcus faecalis, Enterococcus faecium, antimicrobial resistanceTurkiye Klinikleri J Med Sci 2006, 26:477-482
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