ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Adiponectin And Other Cytokines: Medical Education
Dr. Rıfat EMRALa
aEndokrinoloji ve Metabolizma Hastalıkları BD, Ankara Üniversitesi Tıp Fakültesi, ANKARA
It is now recognized that the white adipose tissue produces a variety of bioactive peptides, collectively termed adipocytokines. Alteration of white adipose tissue mass in obesity or lipoatrophy, affects the production of most of these adipose tissue derived factors. Since both conditions are associated with multiple metabolic disorders and increased risk of cardiovascular diseases, the idea has emerged that white adipose tissue may be involved in the development of these complications, by virtue of its secreted factors. Several adipokines are increased in the obese state and have been implicated in hypertension (angiotensinogen), impaired fibrinolysis (plasminogen activator inhibitor-1) and insulin resistance (acylation-stimulating protein, TNF, IL-6, resistin). Conversely, leptin and adiponectin both exert an insulin-sensitizing effect. In obesity, insulin resistance has been linked to leptin resistance and decreased plasma adiponectin. In the recent future, development of new drugs targeting adipokines might represent a promising therapeutic approach to protect obese patients from insulin resistance and atherosclerosis.Keywords: Adiponectin, cytokinesTurkiye Klinikleri J Med Sci 2006, 26:409-420
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