ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Relation Between Mean Platelet Volume And Risk Factors For Coronary Heart Disease
Dr. Serkan KESKİN,a Dr. Müjgan GÜRLER, a Dr. Ela TEMELOĞLU, a
Dr. Aslan ÇELEBİ, a Dr. Rıza ALİCANOĞLU, a Dr. İsmail EKİZOĞLUa
a2. Dahiliye Kliniği, Taksim Eğitim ve Araştırma Hastanesi, İSTANBUL
Objective: Platelets have a significant role in the pathogenesis of atherosclerosis. It is well established that mean platelet volume (MPV) levels increase in acute coronary syndromes. In our study, we defined the relation between the platelet count, MPV levels and the risk factors for coronary heart disease in healthy people.
Material and Methods: Our study group comprised 76 healthy individuals (19 men, 57 women, mean age 41 ± 13). After 12 hours of fasting, we examined their platelet counts, MPV, total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, VLDL cholesterol, fibrinogen, and C reactive protein levels. Risk factors for coronary heart diseases such as age, sexuality and smoking were described. Diabetic patients were not included. We applied Pearson correlation test on the data for defining the relation between platelet count, MPV and coronary artery disease.
Results: The group of patients with LDL cholesterol levels under 100 had an MPV of 8.31 ± 0.77, the group with LDL levels of 100-130 had an MPV of 8.46 ± 0.73, and the group with LDL levels over 130 had an MPV of 8.60 ± 0.70. There was no statistically significant difference between these groups. In the group with a CRP level <4 MPV was 8.49 ± 0.69 and in the group with a CRP level >4 MPV was 8.25 ± 0.87. In the non-smokers group the MPV was 8.36 ± 0.75, the group smoking <10 cigarettes everyday had an MPV of 8.55 ± 0.7, and for the group smoking >10 cigarettes everyday MPV was 8.61 ± 0.72. There was no statistically significant difference between the smoking and the non- smoking groups.
Conclusion: We could not determine a correlation between atherosclerosis and platelet volumes. We suggest that MPV is not a risk factor for coroner artery disease; however it may have a role in the pathogenesis. In association with the results of other studies, we determined that MPV levels increased in acute ischemic lesions, and they returned to normal when the acute lesion improved.Keywords: Coronary arteriosclerosis, blood plateletsTurkiye Klinikleri J Med Sci 2006, 26:380-384
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