ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect On Bone-mineral Density Of Perindopril As An Antihypertensive Drug In Osteoporosis Patients
Dr. Ferda ÖZDEMİR,a Dr. Nurettin TAŞTEKİN,a Dr. Coşkun ZATERİa
aFiziksel Tıp ve Rehabilitasyon AD, Trakya Üniversitesi Tıp Fakültesi, EDİRNE
Objective: The purpose of this study was to investigate the effect on bone-mineral density (BMD) of perindopril as an antihypertensive treatment in conjunction with osteoporosis treatment in hypertensive postmenopausal women.
Material and Methods: Seventy postmenopausal women treated with alendronate were enrolled in this study. Menopausal women with osteoporosis and mild or moderate hypertension were administered perindopril 4 mg/day, alendronate 70 mg/week and calcium 1000 mg/day (group 1; n= 36 patients). The other group consisted of postmenopausal women without hypertension treated by alendronate 70 mg/week and calcium 1000 mg/day (group 2; n= 34 patients). BMD of patients was evaluated before and after 1 year of treatment.
Results: BMD results suggested significant improvements in L2-L4, L2 and L4 scores in both groups after 1 year of treatment. For the L3 score, although there was no difference in group 1, improvement was detected in group 2. In the trochanter region, we did not observe a significant improvement in any group; however, significant improvement was detected in the femur neck only in group 2. There was no significant difference in BMD values between the two groups after treatment (p> 0.05).
Conclusion: In conclusion, according to the results of 1-year treatment, the use of perindopril for concurrent hypertension in patients using alendronate for postmenopausal osteoporosis does not have a clear negative effect on BMD values.Keywords: Osteoporosis, postmenopausal, perindopril, bone densityTurkiye Klinikleri J Med Sci 2006, 26:375-379
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