ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Ghrelin And Its Biochemical Functions: Review
Dr. Süleyman AYDIN,a Dr. Yusuf ÖZKAN,b Dr. Emrah CAYLAK,a Dr. Suna AYDINc
aBiyokimya ve Klinik Biyokimya AD, bEndokrinoloji ve Metabolizma Hastalıkları BD,
cKalp Damar Cerrahisi AD, Fırat Üniversitesi Tıp Fakültesi, ELAZIĞ
Ghrelin (also known as hunger hormone) is an orexigenic peptide hormone composed of 28 amino acid residues. It was discovered by Japanese scientists in 1999. After its discovery, it is considered a counterpart to leptin. Although this peptide is predominantly synthesized in the stomach, it is also expressed in the hypothalamus, pituitary gland, salivary gland, thyroid gland, intestine, kidney, heart, α-cells of pancreatic islets, and gonads. Moreover, ghrelin mRNA is present in the following tissues; stomach, atrium, breast, buccal mucosa, esophagus, fallopian tube, fat tissue, gall bladder, human lymphocytes, ileum, kidney, left colon, liver, lung, lymph node, muscle, myocardium, ovary, pancreas, pituitary, placenta, prostate, right colon, skin, spleen, testis, thyroid, and venous vessels.
Ghrelin plays an important role in the feeding behavior of animals and in appetite regulation in humans. Its secretion in the stomach depends on both acute and chronic changes in the energy balance. In the human organism, ghrelin stimulates secretion of growth hormone, prolactin, and ACTH. In addition to these main effects, ghrelin influences the cardiovascular and gastrointestinal systems. Plasma levels of ghrelin in humans correlate negatively with body mass index. Thus, its abnormal activity leads to over- or underweight. This review summarizes the current knowledge on ghrelin and its implications in health.Keywords: Ghrelin, appetite regulationTurkiye Klinikleri J Med Sci 2006, 26:272-283
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