ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Octreotide On Portal Vein And Peritoneal Fluid Cytokine Levels ,in Postoperative Adhesion Prevention
Ömer GÜNAL, MD,a Mustafa DENİZ,b Arif ASLANER, MD,a Salah GHADOURI, MDb
aDepartment of General Surgery, Abant İzzet Baysal University, Düzce School of Medicine, DÜZCE
bDepartment of Physiology, Marmara University School of Medicine, İSTANBUL
Objective: The aim of this study is to investigate the effect of octreotide on portal vein and peritoneal fluid TNF-α and IL-6 levels in the postoperative adhesion formation. ±
Material and Methods: Following an “adhesion model operation”, 10 rats were given octreotide subcutaneously (25 µg/kg/day) for 10 days (study group) while other 10 rats did not receive any treatment (control group). Ten rats had only a midline laparotomy as sham. Adhesion scores, portal vein and peritoneal fluid cytokine levels were determined on the postoperative 10th day.
Results: Octreotide significantly reduced the total adhesion score. It has also reduced the portal vein IL-6 and TNF- α (147 ± 2 pg/mL; 146.7 ± 2.6 pg/mL respectively) levels as compared to those of control group (193.5 ± 10 pg/mL; 195.8 ± 11.2 pg/mL respectively). There was no reduction (IL-6 132; 143 and TNF-α 132.8; 143.7) on contrary, elevations in peritoneal fluid cytokine levels, comparing to control.
Conclusion: Octreotide reduces postoperative intraabdominal adhesion formation through the mechanisms those mediated by intestinal rather than peritoneal cytokine production.Keywords: Adhesion, cytokine, octreotideTurkiye Klinikleri J Med Sci 2006, 26:252-257
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