ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
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Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Biologic Effects Of Purified Beeswax As An Implant Material (experimental Study)
Dr. Aykut MISIRLIOĞLU,a Dr. Semih GÖK,a Dr Aylin Ege GÜL,b Dr. Güray KILIÇ,c Dr. Tayfun AKÖZa
aPlastik ve Rekonstrüktif Cerrahi Kliniği, bPatoloji Kliniği, Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, cPatoloji Kliniği, Haydarpaşa Numune Hastanesi, İSTANBUL
Objective: To investigate tissue reactions of purified beeswax as an implantation material in an experimental study.
Material and Methods: Forty-nine Wistar male rats were enrolled in the study. In group 1 (n= 20), approximately 1 x 1 x 0.5 cm beeswax tablets and in group 2 (n= 20), 1 x 1 x 0.5 cm silicone blocks were used as implantation material. All implants were placed on the toracodorsal region and each rat had only one implant. In Group-3, which was the negative control group, only toracodorsal dissection was performed in nine rats. Biopsies were obtained at 3, 6 and 9 months and tissue sections were analyzed for the following parameters: capsule formation, capsule thickness, granulation and collagen tissue formation.
Results: At 3 months, there was no significant difference between beeswax and silicone implants. At 9 months of the follow-up, purified beeswax seemed to cause less tissue reactions (p< 0.05) than the silicone implant. Group 3 with toracodorsal dissection alone had normal wound healing processes with minimal fibrosis.
Conclusion: Although this in vivo experimental model showed that purified beeswax implants were biocompatible and caused less tissue reactions than silicone implants, the follow up period was not long enough to demonstrate its long-term effects and further studies on the subject are required.Keywords: Beeswax, siliconesTurkiye Klinikleri J Med Sci 2006, 26:245-251
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