ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Role Of Sex And Thyroid Hormones In The Etiopathogenesis Of Melasma In Men
Dr. Ayça CORDAN YAZICI,a Dr. Kıymet BAZ,a Dr. Güliz İKİZOĞLU,a Dr. Hale ÜZÜMLÜ,a Dr. Deniz DEMİRSEREN,b Dr. Lülüfer TAMER,c Dr. Bahar TAŞDELENd
aDermatoloji AD, cBiyokimya AD, dBiyoistatistik AD, Mersin Üniversitesi Tıp Fakültesi, MERSİN
bDermatoloji Bölümü, Ankara Atatürk Eğitim ve Araştırma Hastanesi, ANKARA
Objective: Melasma is an acquired, irregularly patterned, light to dark brown hypermelanosis in symmetric distribution over the forehead, upper lips, cheeks, chin and rarely forearms. In men, it is much less common than in women. In women, estrogens and progesterone have been implicated in the pathogenesis of melasma. In addition, it is reported that the circulating luteinizing hormone (LH) was significantly higher and testosterone was markedly low among melasmic men. In this study, we aimed to determine whether circulating levels of LH, follicular stimulating hormone (FSH), testosterone estradiol, progesterone, and thyroid hormones play a role in the etiopathogenesis of melasma in men.
Material and Methods: We evaluated circulating levels of LH, FSH, testosterone, estradiol, progesterone, free T3 (fT3), free T4 (fT4), and thyroid stimulating hormone (TSH) in 13 men with idiopathic melasma and compared the results with 14 age matched control subjects. Wood’s lamp was used to determine whether melasma was epidermal, dermal, mixed or indetermined. In addition, three clinical patterns of melasma (centrofacial, malar, mandibular) were determined in the patient group.
Results: There was no statistically significant difference between the patient and control groups in circulating levels of LH, FSH, testosterone, estradiol, progesterone, fT3, fT4, and TSH (p> 0.05). Seven patients (53.8%) had epidermal melasma. Three patients (23.1%) manifested as mixed type and the remaining 3 (23.1%) had dermal melasma. The clinical patterns of melasma were determined as centrofacial type in 9 (69.2%) and malar type in 4 (30.8%) patients.
Conclusion: The present study indicates no hormonal imbalance of sex and thyroid hormones in men with melasma in comparison with age-matched controls.Keywords: Melanosis, men, sex and thyroid hormonesTurkiye Klinikleri J Med Sci 2006, 26:240-244
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