ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Possible Roles Of Microchimerism ın The Pathogenesis Of Autoimmune Disorders?
Dr. Azize Yasemin GÖKSUa
aMikrobiyoloji ve Klinik Mikrobiyoloji AD, Süleyman Demirel Üniversitesi Tıp Fakültesi, ISPARTA
Microchimerism refers to the presence of a small amount of DNA or cells originating from one individual, in another individual. In other words, microchimerism represents the presence of two genetically distinct and separately derived populations of cells, one population being at a low concentration, in the same individual or an organ. During normal human pregnancy, fetal DNA and cells pass into the maternal circulation. Maternal cells may also be detected in the fetal circulation. The most common and natural source of microchimerism is pregnancy. During pregnancy, bi-directional trafficking of hematopoietic cells occurs through the placenta and these microchimeric cells persist for decades after childbirth. In 1996, Bianchi et al reported that fetal cells could survive in the maternal circulation for up to 27 years after parturition. Chimerism may also occur iatrogenic, rather than by natural sources. It is well known that chronic graft-versus-host disease (cGvHD) shares similarities with some autoimmune diseases and is an iatrogenic form of chimerism, occurring as a complication of hematopoietic stem cell transplantation. The Human Leukocyte Antigen (HLA) genes of the donor and the host are known to be of central importance to the development of cGvHD. When also considered in light of the female predilection to autoimmunity and a peak incidence of autoimmune diseases-especially of systemic sclerosis (SSc)-after parturition, these series of observations led to the hypothesis that microchimerism and HLA genes of host and non-host cells are involved in some autoimmune diseases. In other words, persistent fetal cells in the maternal circulation could mediate a graft-versus-host reaction, resulting in autoimmune diseases.Keywords: Fetus, pregnancy, chimerism, autoimmune diseasesTurkiye Klinikleri J Med Sci 2006, 26:163-168
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