ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Findings Of Lens And Fundus Examination ın Patients With Alopecia Areata
Dr. Ayça CORDAN YAZICI,a Dr. Ufuk ADIGÜZEL,b Dr. Özlem YILDIRIM,b
Dr. Dilek ÜSTÜNSOY,a Dr. Kıymet BAZ,a Dr. Güliz İKİZOĞLUa
aDermatoloji AD, bGöz Hastalıkları AD, Mersin Üniversitesi Tıp Fakültesi, MERSİN
Objective: Alopecia areata is a common autoimmune disorder, characterized by localized loss of hair without any subjective symptoms. Ocular alterations ranging from cataract to minor punctate opacities and involvement of the chorioretina were previously reported in alopecia areata. However, there are contradictory results as to the prevalence of these lens and fundus changes. We aimed to determine the ocular alterations and their prevalence in patients with alopecia areata.
Material and Methods: Fifty-two patients with alopecia areata (24 female, 28 male) were examined. Thirty-five healthy controls (16 female, 19 male) unaffected by skin, ocular or systemic disorders were also studied. Patients and controls were referred to Ophthalmology outpatient clinic of Mersin University Hospital for ophthalmological examination including slit-lamp examination.
Results: Asymptomatic punctate lens opacities were presenet in 43 (82.7%) patients and in 29 (82.9%) control subjects. Cataract was not detected in any group. There was no statistically significant difference between the patient and control groups in punctate lens opacities and fundus alterations (p> 0.05). However the difference in posterior capsular irregularities that were observed in 34.6% of the patients and in 2.9% of the controls was statistically significant (p= 0.000). Furthermore, posterior capsular irregularities were much more pronounced in patients who received systemic steroid therapy (p= 0.011).
Conclusion: Ocular alterations and their prevalence in alopecia areata are reported and some theories regarding the possible etiopathogenetic mechanism are discussed. Our data suggests that lens opacities and fundus changes in patients with alopecia areata do not have any significant clinical relevance. However, posterior capsular irregularities which may be the first signs of cataract were detected in patients, particularly in those who received systemic corticosteroid therapy, indicating that utmost care should be taken to avoid such ocular complications in patients with alopecia areata who receive these agents.Keywords: Alopecia areata, cataract, fundus oculiTurkiye Klinikleri J Med Sci 2006, 26:140-145
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