ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Homocysteine, Folate, And Vitamin B12 Levels ın Pregnant And Non-pregnant Women
Özlem ÖZTÜRK, MD,a Serkan KARAER, MD, a Dilara UNCU, MD, a Aytün EFESOY, MDa
aDepartment of Central Biochemistry, Ankara Numune Training and Research Hospital, ANKARA
Objective: To assess the serum homocysteine (tHcy) status of the second trimester pregnant women, aged 18-42 years, and to compare the results with the age-matched non-pregnant women.
Material and Methods: Forty-one pregnant women (24-28 weeks of gestation) aged 18-42 years and 44 healthy non-pregnant women aged 19-35 years were included in the study. tHcy, folate, vitamin B12 and albumin levels were measured and correlated to homocysteine values.
Results: The second trimester pregnant women’s homocysteine levels were significantly lower while folate and vitamin B12 levels were significantly higher than non-pregnant women (p< 0.001). The overall mean homocysteine concentration of the pregnant subjects (3.6 ± 1.59 µmol/L) was significantly lower than those observed in the non-pregnant control group (9.64 ± 1.87 µmol/L) (p< 0.001). Homocysteine levels were positively correlated with albumin levels and negatively correlated with folate and vitamin B12 levels in both pregnant and non-pregnant groups.
Conclusion: The decrease in homocysteine levels during pregnancy seems to be associated with physiologic low levels of albumin and with using prenatal multivitamin supplementation.Keywords: Homocysteine, pregnancy, folic acid, vitamin B12, albuminTurkiye Klinikleri J Med Sci 2006, 26:121-125
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