ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of 5-fluorouracil And Cisplatin On Ca 125, Ca 15-3 And Ca 19-9 Laboratory Results
Abdurrahman COŞKUN, MD,a Özlem YAVUZ, MD, a İbrahim E. ŞAHİN, MD, a Selver GÜLER, MDa
aDepartment of Clinical Biochemistry, Abant İzzet Baysal University, Düzce School of Medicine, DÜZCE
Objective: In this study, we aimed to investigate the interference of 5- Fluorouracil (5-FU), cisplatin and their combination on laboratory results of CA 125, CA 15-3 and CA 19-9.
Material and Methods: Blood samples were collected from ten volunteer donors who had not taken any medications. Each of these 10 blood samples were divided into four aliquots to form the control, 5-FU, cisplatin and 5-FU + cisplatin combination groups. Adequate amount of 5-FU, cisplatin and 5-FU + cisplatin combination, in accordance with maximum therapeutic plasma concentration, were added to aliquots. Serum CA 125 was determined by immunometric method, and CA 15-3 and CA 19-9 were determined by chemiluminescent immunometric method in each group.
Results: Compared to control groups, we observed that 5-FU and cisplatin had positive interference effect on CA 125 and CA 19-9 laboratory results (p< 0.05), whereas no interference of these drugs was observed on CA 15-3 laboratory results (p> 0.05).
Conclusion: We concluded that to obtain accurate laboratory results of tumor markers, interference of chemotherapeutic agents that were used to treat these patients should be considered.Keywords: Fluorouracil, cisplatin, tumor markersTurkiye Klinikleri J Med Sci 2006, 26:117-120
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