ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Orlistat Therapy On Serum Levels Of Vitamins A, E, C And Oxidative Stress
Yusuf ÖZKAN*, Hasan GÜNEY**, Süleyman Serdar KOCA**, Fikret KARATAŞ***, Emir DÖNDER****
* Yrd.Doç.Dr., Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları AD,
** Arş.Gör.Dr., Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları AD,
*** Yrd.Doç.Dr., Fırat Üniversitesi Fen Edebiyat Fakültesi Kimya AD,
**** Prof.Dr., Fırat Üniversitesi Tıp Fakültesi İç Hastalıkları AD, ELAZIĞ
Objective: To evaluate the effects of Orlistat treatment for 12 weeks on the levels of vitamin A, E and C as well as on the level of malondialdehyde (MDA) which increase due to oxidative stress and which is one of the end products of lipid peroxidation.
Materials and Methods: 30 volunteer people (26 female and 4 male people who were older than 20; body-mass indexes equals to or greater than 30) recruited to the study who were being followed in Internal medicine department of Medical School of Firat University and who want to lose weight. The patients underwent physical examination. Their length, weight and body-mass indexes (BMI) were measured. Their whole blood counts, blood biochemical parameters and lipid analyses were evaluated. Serum lev-els of vitamins A, E and C and serum MDA levels were measured by high-performance liquid chromatography (HPLC). All of the participants were begun a diet of 24 Cal/kg as determined by their ideal body weight with Orlistat treatment (120 mg tree times daily). At the end of study period of 12 weeks, all of the parameters initially studied were controlled again.
Results: Mean weight (p<0.05), BMI (p<0.05), total cholesterol level (p<0.05), LDL-cholesterol level (p<0.05) and triglyc-eride levels (p<0.05) decreased significantly after the study period of 12 weeks whereas HDL-cholesterol level raised significantly (p<0.05). Serum levels of vitamins A, E and C decreased significantly (p = 0.000). Serum MDA level de-creased significantly (p = 0.000). A negative correlation was observed between decrease in the serum levels of vitamins A, E and C and increase in serum level of MDA.
Conclusion: Serum levels of vitamins A, E and C decreased significantly after Orlistat treatment for 12 weeks compared to the initial values whereas serum MDA level rose signifi-cantly. Thus, we consider that the serum levels of vitamins A, E and C levels should be followed closely in whom a long-term Orlistat treatment scheduled and those who are receiving such a long-term Orlistat treatment should be given a treatment containing these vitamins when necessaryKeywords: Obesity, orlistat, Anti-Obesity Agents, Vitamin A, Vitamin C, Vitamin E, MalondialdehydeTurkiye Klinikleri J Med Sci 2003, 23:464-470
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