ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Efficiency Of Two-dose Hepatitis B Vaccination In Health Care Workers For Immunoprophylaxis
Dr. Oğuz KARABAY, aDr. Ali TAMER, bDr. Nevin KOÇ İNCE,a Nisa BÜYÜKAHRAZ, cDr. Şeref VARDIb
aKlinik Mikrobiyoloji ve Enfeksiyon Hastalıkları AD, bİç Hastalıkları AD, cEnfeksiyon Kontrol Hemşiresi, Abant İzzet Baysal Üniversitesi, İzzet Baysal Tıp Fakültesi, BOLU
Objective: Previous studies showed that 2 dose vaccinations 4 months apart were as effective as 3 dose vaccination schedules. In this study, we aimed to investigate the reliability and efficiency of 2 doses of Hepatitis B vaccine in health care workers.
Material and Methods: Two dose and 3 dose vaccination groups who were negative for HBsAg, anti-HBcIgG and anti-HBs were selected among health care workers working in the İzzet Baysal Medical Faculty and were randomized in a 1:1 ratio. The 2 dose group included 36 subjects and 33 subjects were present in the 3 dose group. The 2 dose group was vaccinated with 20 μg of vaccine at 0 and 4 months and the same dose was administered to the 3 dose group at 0, 1, and 6 months. Geometric Mean Titers (GMT) were calculated by measuring the level of anti-HBs quantitatively 2 months after the last shot in both groups.
Results: GMT values of the 2 and 3 dose groups were determined as 314.5 and 599.2 IU/mL, respectively (p< 0.01). While the number of subjects with antibody titers under the protective level (anti-HBs<10 IU/mL) was 11 in the 2 dose group, only 1 patient in the 3 dose group had low antibody levels at the end of the vaccination schedule (p< 0.05). No significant difference was observed in terms of adverse effects between the 2 groups (p> 0.05).
Conclusion: Although encouraging results were obtained in recent studies, the 2 dose vaccination schedule at 0 and 4 months used in our study for hepatitis B prophylaxis in health care workers was not as effective as the standard schedule. Thus, larger studies are required.Keywords: Hepatitis B, vaccinationTurkiye Klinikleri J Med Sci 2006, 26:24-28
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