ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Role Of Ca 72-4, A New Tumor Marker In Gastric Cancer
Dr. Vedat GÖRAL,a Dr. Haluk YEŞİLBAĞDAN, b
Dr. Abdurahman KAPLAN, c Dr. Dede ŞİT, b Dr. Murat ÇELİKb
aGastroenteroloji BD, bİç Hastalıkları AD, cBiyokimya AD, Dicle Üniversitesi Tıp Fakültesi, DİYARBAKIR
Objective: Gastric cancer is among the most frequent malignancies throughout the world. Many studies are carried out with tumor markers, tumor suppressive genes and oncogenes in the diagnosis of gastric cancers and the prediction of prognosis. The role of CA 72-4, a new tumor marker in the diagnosis of gastric cancer, and the correlation between CA 72-4 and CA 19-9, CA 15-3, CA 125, carcinoembryonic antigen (CEA) were investigated in this study.
Material and Methods: CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, erythrocyte sedimentation rate, AST, ALT, albumin and hematocrit values were examined in patients with gastric cancer. Age, sex, clinical manifestations, physical examination findings, localization (proximal/distal) and histological typing of the tumor according to Lauren classification, lymph node involvement, metastasis state, and tumor grade and the patient’s performance status were evaluated.
Results: Serum CEA, CA 19-9, CA 125, CA 15-3 levels were quite high in our study patients with gastric cancer. All patients whose CA 72-4 level was over 100 U/mL were advanced cases (grade IV). These 4 markers seemed to increase relatively consistently with tumor involvement and tumor grade. Although CA 72-4 is more sensitive, all other tumor markers except for CA 15-3 play an important role in the diagnosis and determining the prognosis in patients with gastric cancer. We determined that the serum CA 72-4 level in the group with cancer was significantly elevated with respect to the control group. This elevation was correlated with tumor expansion and tumor grade. Particularly in patients with liver metastases, CA 72-4 level was higher.
Conclusion: We suggest that CA 72-4 level is a valuable parameter in determining the prognosis of gastric cancer and recommend its use as a laboratory test.Keywords: Gastric cancer, tumor markersTurkiye Klinikleri J Med Sci 2006, 26:3-8
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