ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Non-alcoholic Fatty Liver Disease: Review
Dr. Başak GÖREN,a Dr. Turgay FENb
aDahiliye Kliniği, bHematoloji Kliniği, Ankara Onkoloji Eğitim ve Araştırma Hastanesi, ANKARA
Non-alcoholic fatty liver disease is a hepatic disorder with histological features of alcohol induced fatty liver disease in individuals who consume no alcohol. Non-alcoholic fatty liver disease refers to a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Non-alcoholic fatty liver disease is the most common chronic liver disease in developed countries, largely due to obesity, type 2 diabetes, hyperlipidemia and insulin resistance. The clinical importance of non-alcoholic fatty liver disease is derived mostly from its common occurrence in the general population and its potential to progress to cirrhosis and liver failure. Whereas simple steatosis has a benign clinical course, non-alcoholic steatohepatitis is a subgroup with specific diagnostic features and a greater risk of progressive fibrosis, cirrhosis and end-stage liver disease. The two-hit theory best describes the progression from simple steatosis to non-alcoholic steatohepatitis, fibrosis and cirrhosis. These two hits consist of the accumulation of excessive hepatic fat due to insulin resistance and oxidative stress attributed to reactive oxygen species. Laboratory tests and imaging studies are not able to distinguish steatosis from steatohepatitis, which requires liver biopsy and histopathological evaluation. Currently, treatment is focused on modifying risk factors such as obesity, diabetes mellitus, and hyperlipidemia. In most cases, treatment aims to achieve gradual weight loss of around 10% of body weight over 6 months and to maintain this. Antioxidants such as vitamin E, N-acetylcysteine may be beneficial in the treatment of non-alcoholic steatohepatitis. The current and potential future treatment strategies for nonalcoholic fatty liver disease are discussed in this article.Keywords: Liver diseases, hepatitisTurkiye Klinikleri J Med Sci 2005, 25:841-850
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