ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Hla System: Review
Dr. Füsun Zeynep AKÇAMa
aEnfeksiyon Hastalıkları AD, Süleyman Demirel Üniversitesi Tıp Fakültesi, ISPARTA
The formation of Human Leukocyte Antigen (HLA), which is named so after it was first defined in leukocytes, is under the control of a gene region, which is called Major Histocompatibility Complex (MHC) Gene Region. This region consists of three main groups which are the MHC Class I (HLA-I, -B, -C, -E, -F, -G), MHC Class II (HLA-DR, -DP, -DQ, -DO, DN) and MHC Class III (C2, C4A, C4B, PF, TNF- a, b) antigens. In each locus of MHC gene region, there are allele genes each of which is responsible for a different antigen. HLA alleles and their products are called HLA antigens. HLA antigens are mobile. Lymphocytes, which have lost their HLA antigens, can reproduce them in 6 hours. Detection of HLA antigens has been used in anthropological investigations. The most important field of use is the histocompatibility examination in tissue and organ transplantation. It may also be used with blood group antigens in paternity determination. Lately, the most studied subject is the association of HLA antigens with diseases. Certain HLA types are more frequent in some diseases. Studies show that genetic factors of the host are responsible for susceptibility to infections, and a high heredity exists in cellular or humoral immune response to pathogen antigens.Keywords: HLA antigens, transplantation, major histocompatibility complex, antigensTurkiye Klinikleri J Med Sci 2005, 25:829-834
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