ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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A Basement Membrane Glycoprotein: Nidogen: Review
Dr. Hakan ÖNER,a Dr. Jale ÖNERa
aHistoloji ve Embriyoloji AD, Akdeniz Üniversitesi Veteriner Fakültesi, BURDUR
Nidogen (Entactin) is a major component of basement membranes (BMs) and, owing to its ability to form complexes with Laminin, type IV collagen, perlecan and the fibulins, plays an important role in the formation of BMs. In mammals, two isoforms of Nidogen present as Nidogen/Entactin-1 (N/E-1) and Nidogen/Entactin-2 (N/E-2). Both N/E isoforms are synthesized mainly by mesenchymal cells. N/E-2 is prominently localized in endothelial BMs. N/E-1 binds to type IV collagen and Laminin-1 and is capable of forming ternary complexes with Laminin-1 and type IV collagen. N/E-2 interacts with type I and IV collagens and perlecan with the same affinity as N/E-1. N/E-2 is bound to Laminin with a lower affinity than N/E-1. N/E-2 is, unlike N/E-1, unable to bind fibulin-1 and -2. N/E-2 is also able to adhere to endostatin and tropoelastin, whereas N/E-1 has not this binding peculiarity. Since its discovery, N/E-1 has been found to promote BM formation, cell attachment, neutrophil chemotaxis, trophoblast outgrowth and angiogenesis. Thus, whether or not similar nidogen isoforms have corresponding traits in all embryonic and adult tissues would appear to be a question worth investigating.Keywords: Basement membrane, EntactinTurkiye Klinikleri J Med Sci 2005, 25:688-692
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