ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Evaluation Of Dysphonia In Asthmatics Treated With Inhaled Corticosteroid
Dr. Mesut S. TEZER,a Dr. Işıl OLCAY,bDr. Müge ÖZCAN,a Dr. Vedat YETENER,c Dr. Serkan CEYHAN,a Dr. Adnan ÜNALa
a1. Kulak Burun Boğaz Kliniği, bGöğüs Hastalıkları Kliniği, cMikrobiyoloji Kliniği, Ankara Numune Eğitim ve Araştırma Hastanesi, ANKARA
Objective: Budesonide inhalation is a first-line therapy in bronchial asthma and has minimal side effects. Dysphonia is one of the most frequent local side effects of inhaled corticosteroids.
Material and Methods: In this study, 35 adults with bronchial asthma and dysphonia (15 men and 20 women; mean age 35.7 years; duration of asthma more than 2 years) underwent video laryngostroboscopic evaluation (VLS).
Results: Dysphonia was mild in 24 patients (68.6%), moderate in 6 patients (17.1%) and severe in 5 patients (14.3%). On VLS, there was vocal cord atrophy in 13 patients (37.1%), glottic gap in 11 patients (31.4%), chronic mucosal disease of the vocal cords in 4 patients (11.4%), vocal nodules in 3 patients (8.6%), and sulcus vocalis in 2 patients (5.7%). Oropharyngeal cultures were positive for Candida albicans in 7 patients (20%).
Conclusion: Inhaled cortocosteroids may cause dysphonia by means of laryngeal myopathy and irritation of the vocal cord mucosa. However, the cause of dysphonia could not be explained through these mechanisms in all patients.Keywords: Voice disorders, adrenal cortex hormones, asthmaTurkiye Klinikleri J Med Sci 2005, 25:658-662
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