ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Intrarectal Paclitaxel Lavage The Healing Of Rectal Anastomosis: A Comparison With Povidone Iodine
Ömer GÜNAL, MD,a Salah GHANDOURI, MD,b Arif ASLANER, MDa
aDepartment of General Surgery, Abant İzzet Baysal University, Düzce Faculty of Medicine, DÜZCEbDepartment of Physiology, Marmara University Faculty of Medicine, İSTANBUL
Objective: Intraluminal colonic washout with anticancer agents is an alternative option to prevent local recurrences after colorectal cancer resection. However, intracolonic washout with any agent can interfere with anastomotic wound healing. The current study aimed to investigate the effects of intracolonic paclitaxel and povidone-iodine administration on intestinal anastomotic healing.
Material and Methods: Localized intracolonic washout with paclitaxel (3 mg/kg) and povidone iodine (5%) was achieved before and after colorectal anastomosis in two (each consisting of 10) groups of rats. The control group (n= 10) received no medical therapy. Anastomotic bursting pressures, anastomotic hydroxyproline content, and peri anastomotic myeloperoxidase activity were determined.
Results: Bursting pressure was significantly less in the povidone group, while it was slightly elevated in the paclitaxel group when compared to the control group. The hydroxyproline level was significantly increased in the povidone group, while it was found to be decreased in the paclitaxel group. Myeloperoxidase levels were also significantly decreased in both groups when compared to the control group.
Conclusion: Although paclitaxel decreases hydroxyproline production, it does not appear to affect anastomotic bursting pressure. Conversely, povidone iodine decreases anastomotic bursting pressure despite increased hydroxproline synthesis. These data imply that paclitaxel and povidone iodine carry out their effects on anastomotic healing either by altering the quality or quantity of collagen synthesis.Keywords: Paclitaxel, povidone-iodine, colonTurkiye Klinikleri J Med Sci 2005, 25:653-657
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