ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
A Comparison Of Radiotherapy Fractionation Schedules In The Palliative Treatment Of Brain Metastases
Dr. Mehmet KOÇ,a Dr. Vecdi ERTEKİN,a Dr. İhsan KARSLIOĞLU,a Dr. Orhan SEZENa
aRadyasyon Onkolojisi AD, Atatürk Üniversitesi Tıp Fakültesi, ERZURUM
Objective: To investigate the effect of two different radiotherapy (RT) schedules for the palliation and survival of patients with brain metastases.
Material and Methods: Between January 1999 and December 2002, 87 patients whose brain metastasis had been diagnosed, Karnofsky Performance Status (KPS) had been greater than 50%, brain metastases had not been operated and whole brain radiotherapy performed in two different schedules (Group I; 400cGy/5 fraction and Group II 300cGy/10 fraction) were evaluated retrospectively. Twenty five of the patients (28.8%) were female and 62 of them were male (71.2%) whose median age was 54 (range :28-77 years). Patients were evaluated for symptomatic and neurologic palliation rate, disease free survival and overall survival. Furthermore, patients were evaluated for possible associations with disease free and overall survival such as KPS, age, gender, and primary control with univariate and multivariate analyses. Cranial CT or MRI were applied in the pretreatment period and 2nd months of posttreatment period.
Results: Overall survival was 5.84 ± 0.61 months in whole group. In the first group (n= 47), it was (400 cGy/5 fr.) 5.62 ± 0.84 months, and in the second group (n= 40) (300 cGy/10 fr.), it was 6.10 ± 0.87 months. There was no significant difference between two groups according to disease free survival. In univariate and multivariate analyses, there was no significant effect observed of KPS, age, absence of extracranial metastases, number of metastases, gender and primary status on the disease free and overall survival.
Conclusion: Primary aim of the treatment of brain metastases is palliation. In this study, there was no significant difference between the two different radiotherapy schedules according to disease free survival and overall survival. But this condition may be supported with prospective randomized studies before recommending short period treatment schedules for the palliation.Keywords: Brain, neoplasm metastasis, radiotherapy, survivalTurkiye Klinikleri J Med Sci 2005, 25:642-648
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