ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Prevalence Of Malt In Patients With Helicobacter Pylori-positive Chronic Active Gastritis And Duodenal Ulcer
Dr. Aslan ÇELEBİ,a Dr. Rıza ALİCANOĞLU,a Dr. Serkan KESKİN,a Dr. Ela TEMELOĞLU,a
Dr. Deniz KOÇ,a Dr. Deniz ESİN,a Dr. Vildan ERCAN,b Dr. Başak GÖKÇENc
a2. Dahiliye Kliniği, b1. Dahiliye Kliniği, Taksim Eğitim ve Araştırma Hastanesi, İSTANBUL
cİç Hastalıkları Kliniği, Özel Uğurlu Hastanesi, KASTAMONU
Objective: In this study, we aimed to determine the prevalence of mucosa associated lymphatic tissue (MALT) lymphoma in patients who had been diagnosed with either chronic active gastritis or duodenal ulcer on endoscopic examination. In addition, we sought to determine Helicobacter pylori (Hp) intensity and to correlate its relationship to MALT prevalence with regard to the clinical diagnosis.
Material and Methods: Seventy-seven patients were included. Gastric biopsy following upper gastrointestinal endoscopic examination was performed at Taksim Education and Research Hospital between June and November, 1999. Patients who had undergone prior Hp eradication or antibiotic treatment, gastric surgery, as well as those with known systemic disease or malignancies were excluded. Three biopsy specimens were taken from antrum and corpus. These fragments were stained with hematoxylin eosin and modified Giemsa and examined by two pathologists.
Results: Of 77 patients, 30 (39%) were diagnosed with duodenal ulcer and 47 (61%) were shown to have chronic active gastritis. 51 (66.2%) patients were classified as MALT 2 and 3. In both groups, a similar ratio of MALT prevalence was determined. Statistically, the relationship between Hp intensity and antral gastric activity (AGA) was significant (p= 0.0001), while the relationship between corpus gastric activity (CGA) and MALT score was not (p> 0.05). Upon comparing MALT score and AGA, when the MALT score was 1, the ratio of AGA was 1.27 ± 0.83; in MALT 2, the ratio was 1.5 ± 0.93 and in MALT 3 it was 1.81 ± 0.7 (p= 0.044). With regard to CGA, when the MALT score was 1, the ratio was 1.08 ± 0.93; for MALT 2 and 3 the ratios were 0.88 ± 0.83 and 1.28 ± 1.1 (p= 0.601), respectively.
Conclusion: We found that there was not an expressive relationship between MALT score and Hp, and although the relationship between MALT and AGA was significant, it was not with CGA. The contention that no significant difference between MALT and Hp intensity exists is supported by the fact that MALT appears to be more often related to immunological stimulus than Hp intensity. The MALT score of our cases did not exceed class 3 and, in the literature, inflammation usually occurs around the lenfoid follicle. These findings indicate that Hp infection can cause such inflammation.Keywords: Lymphoma, Mucosa-Associated Lymphoid Tissue, Helicobacter pylori, endoscopy, biopsyTurkiye Klinikleri J Med Sci 2005, 25:627-635
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