ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Evaluation Of The Prevalence Of Extrahepatic Findings In Chronic Hepatitis-c Virus Infection
Dr. Ali Kemal KADİROĞLU,a Dr. Vedat GÖRAL,b Dr. Dede ŞİT,a
Dr. Murat ÇELİK,cDr. M. Emin YILMAZd
aİç Hastalıkları AD, bGastroenteroloji BD, dNefroloji BD, Dicle Üniversitesi Tıp Fakültesi, DİYARBAKIR
cİç Hastalıkları Kliniği, Nusaybin Devlet Hastanesi, MARDİN
Objective: To evaluate the prevalence of clinical and biological extrahepatic findings in HCV infection.
Material and Methods: Forty anti-HCV (+) patients and 40 HbsAg (+) patients were evaluated in the study. In the anti-HCV (+) group, 35 of 40 (87.5%) manifested chronic liver disease and 5 of 40 (12.5%) had liver cirrhosis. In the HbsAg (+) group, 33 of 40 (82.5%) were seen to have chronic liver disease and 7 of 40 (17.5%) liver cirrhosis. HCV and HBV infections were confirmed by ELISA and polymerase chain reaction (PCR). Biochemical, hematological and immunological tests were performed for both anti-HCV (+) and HbsAg (+) groups. They were as well evaluated for other clinical presentations, such as rheumatological, dermatological, neurological, and psychiatric symptoms.
Results: In the anti-HCV (+) group, the mean age was 49.0 ± 15.7 years, the mean duration of disease was 38.1 ± 51.8 months. In the HbsAg (+) group, they were, respectively, 36.4 ± 13.2 years and 35.3 ± 42.1 months. Extrahepatic clinical presentations in the anti-HCV (+) group versus HbsAg (+) group were as follows: 25% arthralgia and 5% arthritis versus 5% arthralgia (p= 0.031); 10% paresthesia and 12.5% peripheral neuropathy versus 5% paresthesia (p= 0.041); 10% pruritus versus 5% pruritus (p= 0.045); 50% depression and 2.5% anxiety versus 7.5% depression (p= 0.000); 25% ANA (+), 2.5% ASMA (+) and 7.5% [ANA + ASMA + AMA] (+) versus only 5% ANA (+). A positive correlation was found between clinic status and age (r = 0.429, p= 0.006, r= 0.461, p= 0.003), between clinic status and duration of disease (r= 0.516, p= 0.001, r= 0.517, p= 0.001) and between serum albumin and hct levels (r= 0.561, p= 0.000, r= 0.649, p= 0.000) in the anti-HCV (+) and HbsAg (+) groups, respectively. The relative risk values of each of the extrahepatic findings were established in both groups.
Conclusion: Extrahepatic findings such as rheumatological, neurological, psychiatric and dermatological clinical presentations, as well as autoantibody positivity, were more frequently observed in the anti-HCV (+) group. It was also observed that the prevalence of extrahepatic findings in this clinical setting was more increased in variable ratio in those with chronic HCV infection rather than in normal individuals.Keywords: Infection, prevalance, hepatitisTurkiye Klinikleri J Med Sci 2005, 25:621-626
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