ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Excessive Cigarette Smoking On The Thyroidfunction Tests And Trace Elements
Funda GÜLCÜ*, S. Aytaç POLAT**, M. Ferit GÜRSU***
* Dr., Fırat Üniversitesi Tıp Fakültesi Biyokimya AD, Arş. Gör.,** Yrd.Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Halk Sağlığı AD,*** Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Biyokimya AD, ELAZIĞ
Purpose: In this study, the effects of smoking on thyroid function tests [triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH), free T3 (FrT3) and free T4 (FrT4)] and the levels of trace elements [iron (Fe), copper (Cu), magnesium (Mg), zinc (Zn)] were investigated in excessive smokers.
Materials and Methods: In this case control study, 32 heavy smoker subjects (12-18 cigarette/day) were enrolled as the study group, while the control group was consisted of 31 male subjects who have never smoked. In order to measure serum hormone and trace elements levels, 5 mL of blood samples were taken after a 12 hours fasting period.
Result: The levels of T3, T4 and TSH were decreased by 19-35% in excessive smokers when compared to the controls. The decreases in the thyroid parameters were statistically significant except FrT4 levels. The levels of serum Cu, Fe, Zn and ferritin were significantly decreased (p<0.05). The statistically significant increase in Mg levels in excessive smokers compared to controls drew attention (p<0.01).
Conclusion: According to these results; we have suggested that long term smoking causes hypothyroidism and some problems and it is necessary to supplement the diet with trace elements.Keywords: Smoking, Thyroid Function Tests, Trace elementsTurkiye Klinikleri J Med Sci 2003, 23:386-391
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