ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Bone Mineral Density In Type 2 Diabetes Mellitus
İris KAVALALI ÖKTEM*, Zeliha HEKİMSOY*
*Uz.Dr., İzmir Atatürk Eğitim ve Araştırma Hastanesi, Endokrinoloji ve Metabolizma Hastalıkları Birimi, İZMİR
Purpose: The effect of diabetes mellitus on bone metabolism is disputable in many ways. Type 1 DM, based on an autoimmune process, seems to be associated with low turnover osteopenia. In contrast, patients with type 2 DM, especially overweight women, have a normal or even increased bone mineral density (BMD). Even decreased BMD was shown in some studies with type 2 DM. The heterogenity of results might be explained by the heterogenity of diabetic patients and the different study methods. In the literature, most of the studies questioned the relationship between diabetic complications, poor metabolic control and osteoporosis, and the effects of sex on BMD. The aim of our study was to evaluate the BMD of postmenopausal women treated at the Endocrinology policlinic at our hospital.
Materials and Methods: We studied 36 type 2 diabetic, postmenopausal women treated at the Endocrinology policlinic and 31 age matched postmenopausal, healthy controls. There was no desease or intake of drugs effecting the BMD in any of the two groups and the presence of osteoporosis was measured by dual-energy X-ray absorbtiometry technique.
Results: We found no significant relationship between the patients and control subjects in BMD. But a negative correlation was found between age, postmenopausal age and BMD.
Conclusion: The reason why there was no significant relationship between the patients and control subjects in BMD was probably because of long years of follow up at the policlinic, the exclusion of the patients having diabetic complications effecting bone metabolism and the metabolic regulation of these patients. Considering these reasons, we believe that type 2 diabetic patients under good metabolic control and having no diabetic complications do not have an additional risk of osteoporosis.Keywords: Diabetes Mellitus, Type 2, Bone mineral density, OsteoporosisTurkiye Klinikleri J Med Sci 2003, 23:371-377
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