ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Clinical Manifestations Of The Antiphospholipid Syndrome: Review
Dr. Murat KEKİLLİ,a Dr. Yavuz BEYAZIT,a Dr. Salih AKSU,a,bDr. İbrahim C. HAZNEDAROĞLUa,b
aİç Hastalıkları AD, bHematoloji Ünitesi, Hacettepe Üniversitesi Tıp Fakültesi, ANKARA
The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial or venous thrombosis, recurrent loss of pregnancy, and thrombocytopenia combined with laboratory tests that indicate the presence of antibodies against phospholipid-binding proteins. Clinically relevant APL antibodies are mainly anticardiolipin antibodies detected by solid-phase enzyme-linked immunosorbent assay and lupus anticoagulants demonstrated by in vitro coagulation assay. The condition can cause significant morbidity and even mortality. The term “APS” was first coined to denote the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability. Venous thrombosis occurs mostly in the lower limbs, with or without pulmonary embolism, and cerebral ischemia and transient ischemic attacks are the most common arterial events.Keywords: Antiphospholipid syndrome,antibodies, antiphospholipidTurkiye Klinikleri J Med Sci 2005, 25:565-568
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