ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Brugada Syndrome: Clinical Evaluation, Diagnosis And Treatment Modalities: Review
Dr. Ersan TATLI,aDr. Çetin GÜL,aDr. Hüseyin SÜRÜCÜ,aDr. Fatih ÖZÇELİKa
aKardiyoloji AD, Trakya Üniversitesi Tıp Fakültesi, EDİRNE
Patients without demonstrable structural heart disease and an ECG pattern of right bundle-branch block with ST-segment elevation in leads V1 through V3 are at risk for ventricular fibrillation. The Brugada syndrome is a symptom complex involving these traits and including recurrent syncopal episodes followed by polymorphic ventricular arrhythmias or sudden cardiac death. Generally, there is no association with organic heart disease. It is diagnosed mostly in males in the fourth decade. Mutations in the SCN5A gene encoding voltage-linked Na+ channels on cell membranes have been postulated as the responsible pathophysiology. These gene mutations result in trans-membranous voltage gradients in myocardium due to early inactivation of Na+ channels. Such mutations are also thought to be responsible for certain of the inherited arrhythmogenic diseases (e.g., long QT syndrome, Lenègre disease, and sudden infant death syndrome), of which the Brugada syndrome is one. ST segment elevation might be unmasked with drug challenge in uncertain cases. Subjects at highest risk for cardiac sudden death are those with a familial history of sudden death and syncopal episodes. EPS must be performed on such patients. Patients manifesting ventricular arrhythmias (VT, VF) on EPS must be promptly managed. Amiodarone and/or beta-blockers do not protect against sudden death. Quinine may be used as medical management, but the ICD is the present treatment of choice. In this article, we discuss the diagnosis, clinical evaluation and treatment modalities of the Brugada syndrome.Keywords: Brugada syndrome, diagnosis, therapeuticsTurkiye Klinikleri J Med Sci 2005, 25:560-564
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