ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Decreased Serum Adiponectin Levels In Hypertensive Patients
Dr. Yusuf ÖZKAN,a Dr. Süleyman Serdar KOCA,b Dr. Vedat GENCER,b
Dr. Göksel ÖZALP,b Dr. Emir DÖNDERb
aEndokrinoloji ve Metabolizma Hastalıkları BD, bİç Hastalıkları AD, Fırat Üniversitesi Fırat Tıp Merkezi, ELAZIĞ
Objective: Atherosclerotic vascular diseases are among the leading causes of mortality and morbidity in Western societies. Hypertension (HT) is a major changeable risk factor in atherosclerosis. Adiponectin, which is secreted from adipose tissue, is an anti-inflammatory cytokine with a regressive and protective effect on atherosclerosis. In the present study, we examined serum adiponectin levels in essential hypertension.
Material and Methods: Included were 38 essential hypertension patients who presented in the Fırat Medical Center General Internal Diseases Polyclinic between January and June 2004, as well as 10 healthy individuals. Oral consent was obtained, physical examinations were conducted and demographical characteristics were recorded. In addition to routine blood chemistry, insulin, C-peptide and adiponectin levels were noted. Adiponectin was examined using the ELISA method. The Mann Whitney U test was used in the evaluation of data.
Results: The mean adiponectin level was 18.8 ± 6.8 µg/mL in the healthy individuals and 5.8 ± 2.1 µg/mL in the HT group, the difference therein being statistically significant (p< 0.05). Fasting blood sugar, basal insulin, HOMA IR, total cholesterol, triglyceride, and LDL-cholesterol levels in the hypertensive individuals were significantly higher than those in the control group. The mean adiponectin level was 6.7 ± 2.3 µg/mL in non-obese hypertensive cases and 5.1 ± 1.7 µg/mL in obese hypertensive cases; the difference between the two was statistically significant (p< 0.05). Adiponectin levels in hypertensive patients who did not have a familial diabetes history were significantly lower than those in hypertensive patients with such a history (p< 0.05). Adiponectin levels were also found to be lower in males, smokers and less active hypertensive patients, but the difference was not statistically significant.
Conclusion: Serum levels of adiponectin, an anti-inflammatory cytokine, decrease in the presence of HT. When obesity, sedentary life-style, smoking, diabetes and a familial history of cardiovascular diseases accompany hypertension, serum adiponectin levels show a further decrease.Keywords: Hypertension, atherosclerosis, adiponectinTurkiye Klinikleri J Med Sci 2005, 25:519-524
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