ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Efficiency Of Carbamazepine And Oxcarbazepine In Partial Seizures
Dr. Hacer BOZDEMİR,a Dr. Kezban ASLAN,a Dr. Filiz KOÇ,a Dr. Yakup SARICAa
aNöroloji AD, Çukurova Üniversitesi Tıp Fakültesi, ADANA
Objective: Carbamazepine (CBZ) is a first-choice antiepileptic agent used primarily for partial seizures. In this study, we compare the clinical effects, safety and efficacy of CBZ and oxcarbazepine (OCZ) in patients with partial seizure.
Material and Methods: The mean age of one hundred twenty patients (61 female and 59 male) is 37.61 ± 17.24 (13-75) years old. 60.8% percent (n= 73) of these were administered CBZ and 39.2% (n= 47) OCZ. The mean dosage of CBZ was 517.81 ± 180.54 mg/d (range: 200-1200 mg/d), while the oxcarbazepine dosage was 839.36 ± 340.71 mg/d (range: 450-1800 mg/d).
Results: Statistically, there was no difference between the two groups (p= 0.311) during the control period in terms of seizure activity.
Conclusion: Seizures were well controlled in 80 patients (66.7%); however, in 40 (33.3%) some seizure activity was seen to intermittently occur. We found no differences in seizure frequency in 3 (2.5%) patients. These findings suggest CBZ monotherapy to be more effective than OCZ. Furthermore, CBZ achieved this effectiveness with smaller dosages than OCZ (p< 0.014).Keywords: Carbamazepine, oxcarbazepine, partial, epilepsy and prognosisTurkiye Klinikleri J Med Sci 2005, 25:513-518
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